The series follows the events and concept of the film trilogy, continuing adventures of Frank Martin, a professional freelance courier driver for hire who will deliver anything, anywhere – no questions asked – for the right price, and lives by three "unbreakable" rules, which he constantly breaks. Chris Vance takes over the role of Frank from Jason Statham and is joined by Andrea Osvárt, who plays the leading female role in the series, starring as a former CIA agent and love interest for Frank, who organizes his missions, and François Berléand, the only returning actor from the film series, who reprises his role as Inspector Tarconi.
- Chris Vance as Frank Martin
- Andrea Osvárt as Carla Valeri
- François Berléand as Inspector Tarconi
- Delphine Chanéac as Juliette Dubois
- Charly Hübner as Dieter Hausmann