The Lamborghini Murcielago Roadster was driven by Frank Martin to chase after Gianni Chellini's plane which was taking off from the airfield in Miami. Frank after killing Lola at Gianni's mansion chases after Gianni who is escaping in a helicopter. Frank takes the car from the garage and uses it to chase after Gianni's helicopter. While on the freeway he would interfere in a high speed police chase but would past the police and continue the chase where he ends up boarding the jet by driving onto the runway and climbing onto the jets nose gear resulting in the car to speed up without a driver and crash into the MIAMI sign destroying it.
- Jason Statham owns an Orange Lamborghini Murcielago Roadster in real life.